UNC51-like kinase 1, autophagic regulator and cancer therapeutic target
نویسندگان
چکیده
منابع مشابه
Cancer Therapy: Preclinical Polo-Like Kinase 1 is a Therapeutic Target in High-Risk Neuroblastoma
Purpose: High-risk neuroblastoma remains a therapeutic challenge for pediatric oncologists. The Pololike kinase 1 (PLK1) is highly expressed in many human cancers and is a target of the novel small-molecule inhibitor BI 2536, which has shown promising anticancer activity in adult malignancies. Here, we investigated the effect of BI 2536 on neuroblastoma cells in vitro and in vivo to explore PLK...
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Pancreas cancer is the fourth leading cause of cancer-related death in adults in the United States. New molecular targets for diagnosis and therapy of this disease are desperately needed. In this study, we report on the mitotic serine-threonine kinase polo-like kinase 1 (Plk1) in pancreatic cancer. Plk1 mRNA was found to be overexpressed in 9 of 10 tested pancreatic cancer cell lines and in 4 o...
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Polo-like kinase 1 (Plk1) is a key regulator of progression through mitosis. Although Plk1 seems to be dispensable for entry into mitosis, its role in spindle formation and exit from mitosis is crucial. Recent evidence suggests that a major role of Plk1 in exit from mitosis is the regulation of inhibitors of the anaphase-promoting complex/cyclosome (APC/C), such as the early mitotic inhibitor 1...
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ژورنال
عنوان ژورنال: Cell Proliferation
سال: 2014
ISSN: 0960-7722
DOI: 10.1111/cpr.12145